Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products

• Main Author: Noguchi, Taro (Author, http://id.loc.gov/vocabulary/relators/aut)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Singapore : Springer Singapore : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Series: Springer Theses, Recognizing Outstanding Ph.D. Research,
• Subjects: Medicinal chemistry.; Organic chemistry.; Pharmaceutical technology.; Medicinal Chemistry.; Organic Chemistry.; Pharmaceutical Sciences/Technology.

This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mi...

Table of Contents:

• Introduction
• Development of a Mirror-image Screening Process by Using Synthetic Proteins
• Synthesis of Grb2 SH2 Domain Proteins for Mirror-image Screening Systems
• Conclusions.