Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion

• Main Authors: Marazioti, Antonia, Lilis, Ioannis, Vreka, Malamati, Apostolopoulou, Hara, Kalogeropoulou, Argyro, Giopanou, Ioanna, Giotopoulou, Georgia, Krontira, Anthi, Iliopoulou, Marianthi, Kanellakis, Nikolaos, Agalioti, Theodora, Giannou, Anastasios, Jones-Paris, Celestial, Iwakura, Yoichiro, Kardamakis, Dimitrios, Blackwell, Timothy, Taraviras, Stavros, Spella, Magda, Stathopoulos, Georgios
• Other Authors: Μαραζιώτη, Αντωνία
• Format: Journal (paper)
• Language: English
• Published: 2018
• Subjects: Malignant pleural effusion; KRAS mutations; Mutant KRAS facilitates; IKKα-mediated responsiveness; Κακοήθης υπεζωκοτική συλλογή; Μεταλλάξεις KRAS

Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers. While we previously identified KRAS mutations as molecular culprits of MPE formation, the underlying mechanism remained unknown. Here, we determine that non-canonical IKKα-RelB pathway activation of KRAS-mutant...