Impact of ZBTB7A hypomethylation and expression patterns on treatment response to hydroxyurea

• Main Authors: Chondrou, Vasiliki, Stavrou, Eleana, Markopoulos, Georgios, Kouraklis-Symeonidis, Alexandra, Fotopoulos, Vasilios, Symeonidis, Argiris, Vlachaki, Efthymia, Chalkia, Panagiota, Patrinos, George, Papachatzopoulou, Adamantia, Sgourou, Argyro
• Other Authors: Χονδρού, Βασιλική
• Format: Journal (paper)
• Language: English
• Published: 2019
• Subjects: SCA homozygotes; SCA/β-thal heterozygotes; Hydroxyurea treatment; HbF induction; HBB cluster “modifying genes”; Epigenetic regulation

Background: We aimed to clarify the emerging epigenetic landscape in a group of genes classified as “modifier genes” of the β-type globin genes (HBB cluster), known to operate in trans to accomplish the two natural developmental switches in globin expression, from embryonic to fetal during the first...