Evaluating and optimizing loading methods of single-chain variable fragment protein into extracellular vesicles

• Κύριος συγγραφέας: Mohamed, Khaled
• Άλλοι συγγραφείς: Κλεπετσάνης, Παύλος
• Μορφή: Thesis
• Γλώσσα: English
• Έκδοση: 2020
• Θέματα: Nanosized extracellular vesicles; Protein transfer; FDA; Νανοσωματιδιακά εξωκυτταρικά κυστίδια; Μεταφορά πρωτεϊνών

by the FDA. While commercially available proteins have an extracellular activity, intracellular targets could be a powerful alternative to treat many diseases (cancer, inflammatory disorders,...). Nevertheless, proteins face many barriers to reach their intracellular targets (internalisation, endoso...