The role of HDL metabolic pathways in the development of brown-like phenotype in bone marrow of mice

• Main Author: Καστρενοπούλου, Αφροδίτη Γρηγορία
• Other Authors: Kastrenopoulou, Afroditi Grigoria
• Language: English
• Published: 2020
• Subjects: HDL; Brown adipose tissue (BAT); UCP1; ApoA1; ApoAI; Lipoproteins; Φαιός λιπώδης; Λιποπρωτεΐνες

Brown adipose tissue (BAT) has anabolic effect on osteoblasts. We have recently documented that deficiency of apolipoprotein A1 (ApoA1), key-element of HDL biogenesis, results in decreased osteoblastic function in mice. In the present study we investigated whether ApoA1 deficiency (thus impaired HDL...