Intracellular trafficking and excretion of PEGylated polymer-based nanoparticles in macrophages

• Main Author: Barbieri, Beatriz
• Language: English
• Published: 2022
• Subjects: Polymeric nanoparticles; Intracellular trafficking; Πολυμερικά νανοσωματίδια; Ενδοκυτταρική μεταφορά

Despite the increased interest in the application of nanoparticles (NPs) in medicine, nanotherapeutics still often suffer from a poor pharmacokinetic profile with a short half-life in blood. This is caused by the interactions between NPs and macrophages within the reticuloendothelial system. Macroph...