Study of the genotoxicity mechanisms of all-trans retinoic acid and its analogue EA-4

• Main Author: Alakhras, Raghda Said H.
• Other Authors: Demopoulos, Nikos
• Format: Thesis
• Language: English
• Published: 2011
• Subjects: Retinoids - all-trans retinoic acid; Micronucleation; Chromosome breakage; Chromosome delay; Multinucleation; Mitotic spindle defect; DNA fragmentation; COMET assay; Ρετινοειδή - all-trans ρετινοϊκό οξύ; Μικροπυρήνωση; Χρωμοσωματική θραύση; Χρωμοσωματική καθυστέρηση; Πολυπυρήνωση; Ανωμαλίες μιτωτικής ατράκτου; Κατάτμηση DNA; Μέθοδος COMET; 616.994 061

Vitamin A and its metabolites retinal and retinoic acid are important molecules for the regulation of normal cellular growth, differentiation and other important functions. Retinoids are known to exert mutagenic as well as antimutagenic activity, although conflicting reports are known. All-trans ret...