Identification of drug polymorphs in tablets

• Main Authors: Kontoyannis, Christos, Orkoula, Malvina, Karampas, Ioannis, Zissi, Georgia, Skorda, Dimitra, Serpi, E
• Other Authors: Κοντογιάννης, Χρήστος
• Format: Conference (paper)
• Language: English
• Published: 2012
• Subjects: Polymorphs; Active Pharmaceutical Ingredient (API); Donepezil HCl; Atorvastatin Calcium; X-ray powder diffraction; IR; Crystal phase; Tablets; Πολύμορφα; Δραστική φαρμακευτική ουσία; Υδροχλωρική Δονεπεζίλη; Ατορβαστατίνη; Περίθλαση ακτίνων Χ; Φασματοσκοπία υπερύθρου; Κρυσταλλική φάση; Δισκία

Polymorphs of an Active Pharmaceutical Ingredient (API) can have different chemical and physical properties and, thus, a direct impact on the process-ability of the drug substance and the quality/performance of the drug product, such as stability, dissolution, and bioavailability. Therefore, identif...