Model based characterization of pharmacokinetic interaction between voriconazole and cytarabine in patients with acute myeloid leukemia

• Main Author: Ματθιός, Ανδρέας
• Other Authors: Σιβολαπένκο, Γρηγόριος
• Format: Thesis
• Language: English
• Published: 2014
• Subjects: Voriconazole; Cytarabine; Acute myeloid leukemia; Pharmacokinetic interaction; Βορικοναζόλη; Κυταραβίνη; Οξεία μυελογενή λευχαιμία; Φαρμακοκινητική αλληλεπίδραση; 615.704 5

Voriconazole is a broad spectrum antifungal agent. Patients with acute myeloid leukemia that are susceptible to fungal infections receive simultaneously voriconazole and antitumor regimens. Drug-drug interactions between voriconazole and cytarabine involving the CYP3A4 enzyme are thought to affect t...