6_[9783110288537 - Mathematics] 8.1 Reaction-Diffusion.pdf

In this paper we present mathematical approaches to understand a symmetry break and formation of spatially heterogenous structures during development. We focus on the models given by reaction-diffusion equations and approach the question of possible mechanisms of development of spatially heterogeneo...

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Έκδοση: De Gruyter 2019
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spelling oapen-20.500.12657-237202024-03-22T19:23:05Z Chapter 8.1 Reaction-Diffusion Models of Pattern Formation in Developmental Biology Marciniak-Czochra, Anna Antoniouk, Alexandra V. Melnik, Roderick V. N. Mathematical Method Statistical Method Modeling Method Life Sciences Application thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries::KNDR Vehicle and transport manufacturing industries thema EDItEUR::P Mathematics and Science::PB Mathematics::PBK Calculus and mathematical analysis::PBKS Numerical analysis thema EDItEUR::P Mathematics and Science::PB Mathematics::PBW Applied mathematics thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues In this paper we present mathematical approaches to understand a symmetry break and formation of spatially heterogenous structures during development. We focus on the models given by reaction-diffusion equations and approach the question of possible mechanisms of development of spatially heterogeneous structures. We discuss two mechanisms of pattern formation: diffusion-driven instability (Turing instability) and a hysteresis-driven mechanism, and demonstrate their possibilities and constraints in explaining different aspects of structure formation in cell systems. Depending on the type of nonlinearities, we show the existence of Turing patterns, the maxima of which may be of the spike or plateau type, and the existence of transition layer stationary solutions. These concepts are discussed on example of morphogenesis of the fresh water polyp Hydra, which is a model organism in developmental biology. 2019-11-19 23:55 2020-01-07 16:47:06 2020-04-01T09:26:49Z 2020-04-01T09:26:49Z 2012 chapter 1006424 OCN: 1135845492 9783110273724 http://library.oapen.org/handle/20.500.12657/23720 eng application/pdf n/a 6_[9783110288537 - Mathematics] 8.1 Reaction-Diffusion.pdf De Gruyter Mathematics and Life Sciences 10.1515/9783110288537.191 10.1515/9783110288537.191 2b386f62-fc18-4108-bcf1-ade3ed4cf2f3 971c4d04-5c8e-442e-b04d-c7f4af74d703 7292b17b-f01a-4016-94d3-d7fb5ef9fb79 9783110273724 European Research Council (ERC) Berlin/Boston 210680 FP7 Ideas: European Research Council FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013) open access
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collection DSpace
language English
description In this paper we present mathematical approaches to understand a symmetry break and formation of spatially heterogenous structures during development. We focus on the models given by reaction-diffusion equations and approach the question of possible mechanisms of development of spatially heterogeneous structures. We discuss two mechanisms of pattern formation: diffusion-driven instability (Turing instability) and a hysteresis-driven mechanism, and demonstrate their possibilities and constraints in explaining different aspects of structure formation in cell systems. Depending on the type of nonlinearities, we show the existence of Turing patterns, the maxima of which may be of the spike or plateau type, and the existence of transition layer stationary solutions. These concepts are discussed on example of morphogenesis of the fresh water polyp Hydra, which is a model organism in developmental biology.
title 6_[9783110288537 - Mathematics] 8.1 Reaction-Diffusion.pdf
spellingShingle 6_[9783110288537 - Mathematics] 8.1 Reaction-Diffusion.pdf
title_short 6_[9783110288537 - Mathematics] 8.1 Reaction-Diffusion.pdf
title_full 6_[9783110288537 - Mathematics] 8.1 Reaction-Diffusion.pdf
title_fullStr 6_[9783110288537 - Mathematics] 8.1 Reaction-Diffusion.pdf
title_full_unstemmed 6_[9783110288537 - Mathematics] 8.1 Reaction-Diffusion.pdf
title_sort 6_[9783110288537 - mathematics] 8.1 reaction-diffusion.pdf
publisher De Gruyter
publishDate 2019
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