Clinical trial design : Bayesian and frequentist adaptive methods /

• Κύριος συγγραφέας: Yin, Guosheng (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: Wiley InterScience (Online service)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : John Wiley & Sons, [2012]
• Σειρά: Wiley series in probability and statistics.
• Θέματα: Clinical trials > Statistical methods.; Bayesian statistical decision theory.; Mathematical statistics.; Clinical Trials as Topic > methods.; Bayes Theorem.; Statistics as Topic > methods.; Clinical trials.; Medicine.; MEDICAL > Laboratory Medicine.; Electronic books.

 There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. nevertheless, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. This book provides an overview of the fundamentals of clinical trials, the key terminologies and concepts, and a brief review and comparison on Bayesian and frequentist estimation and inference procedures. From the practical point of view, this book introduces various statistical methods that are commonly. 

 Front Matter -- Introduction -- Fundamentals of Clinical Trials -- Frequentist versus Bayesian Statistics -- Phase I Trial Design -- Phase II Trial Design -- Phase III Trial Design -- Adaptive Randomization -- Late-Onset Toxicity -- Drug-Combination Trials -- Targeted Therapy Design -- References -- Author Index -- Subject Index -- Wiley Series in Probability and Statistics.