Clinical trial design : Bayesian and frequentist adaptive methods /

• Κύριος συγγραφέας: Yin, Guosheng (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: Wiley InterScience (Online service)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : John Wiley & Sons, [2012]
• Σειρά: Wiley series in probability and statistics.
• Θέματα: Clinical trials > Statistical methods.; Bayesian statistical decision theory.; Mathematical statistics.; Clinical Trials as Topic > methods.; Bayes Theorem.; Statistics as Topic > methods.; Clinical trials.; Medicine.; MEDICAL > Laboratory Medicine.; Electronic books.

There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. nevertheless, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. This bo...

Πίνακας περιεχομένων:

• Front Matter
• Introduction
• Fundamentals of Clinical Trials
• Frequentist versus Bayesian Statistics
• Phase I Trial Design
• Phase II Trial Design
• Phase III Trial Design
• Adaptive Randomization
• Late-Onset Toxicity
• Drug-Combination Trials
• Targeted Therapy Design
• References
• Author Index
• Subject Index
• Wiley Series in Probability and Statistics.
• Fundamentals of clinical trials
• Frequentist versus Bayesian statistics
• Phase I trial design
• Phase II trial design
• Phase III trial design
• Adaptive randomization
• Late onset toxicity
• Drug combination trials
• Targeted therapy design.