Down Syndrome : from Understanding the Neurobiology to Therapy /
Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of th...
| Άλλοι συγγραφείς: | , |
|---|---|
| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Amsterdam :
Elsevier,
2012.
|
| Σειρά: | Progress in brain research ;
v. 197. |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Ch. 1. Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future / R. de la Torre and M. Dierssen
- Ch. 2. Genomic determinants in the phenotypic variability of Down syndrome / A. Letourneau and S.E. Antonarakis
- Ch. 3. Intellectual disabilities, neuronal posttranscriptional RNA metabolism, and RNA-binding proteins: three actors for a complex scenario / B. Bardoni [and others]
- Ch. 4. Aberrant epigenetic landscape in intellectual disability / J.V. Sanchez-Mut, D. Huertas and M. Esteller
- Ch. 5. Pathways to cognitive deficits in Down syndrome / X. Sturgeon [and others]
- Ch. 6. Neurological phenotypes for Down syndrome across the life span / I.T. Lott
- Ch. 7. Human and mouse model cognitive phenotypes in Down syndrome: implications for assessment / J.O. Edgin [and others]
- Ch. 8. Perturbation of dendritic protrusions in intellectual disability / J. Levenga and R. Willemsen
- Ch. 9. The in vivo Down syndrome genomic library in mouse / Y. Herault [and others]
- Ch. 10. Discoveries in Down syndrome: moving basic science to clinical care
- A.M. Kleschevnikov [and others]
- Ch. 11. A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome / D.G. Currier, R.C. Polk and R.H. Reeves
- Ch. 12. Gene therapy for Down syndrome / C. Fillat and X. Altafaj.
