Absorption and drug development : solubility, permeability, and charge state /

• Main Author: Avdeef, Alex
• Format: eBook
• Language: English
• Published: Hoboken, N.J. : John Wiley & Sons, Ã2012.
• Subjects: Drugs > Metabolism.; Adsorption.; Drug development.; Drugs > Design.; Medical.; MEDICAL > Drug Guides.; MEDICAL > Nursing > Pharmacology.; MEDICAL > Pharmacology.; MEDICAL > Pharmacy.; Pharmaceutical Preparations > metabolism.; Administration, Oral.; Cell Membrane Permeability.; Pharmaceutical Preparations > chemistry.; Structure-Activity Relationship.; Electronic books.

BExplains how to perform and analyze the results of the latest physicochemical methods/b/ With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug...

Table of Contents:

• Introduction Transport model pKa determination
• Octanol-water partitioning
• Liposome-water partitioning
• Solubility
• Permeability
• Pampa
• Permeability Caco 2/MDCK
• Permeability blood brain barrier.