Bioisosteres in medicinal chemistry.

• Συγγραφή απο Οργανισμό/Αρχή: Wiley InterScience (Online service)
• Άλλοι συγγραφείς: Brown, Nathan (Medicinal chemist), Mannhold, Raimund, 1948-, Kubinyi, Hugo, Folkers, Gerd
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken : Sons, John Wiley & amp ; 2012.
• Σειρά: Methods and principles in medicinal chemistry ; v. 54.
• Θέματα: Drugs > Design.; Pharmaceutical chemistry.; MEDICAL > Drug Guides.; MEDICAL > Nursing > Pharmacology.; MEDICAL > Pharmacology.; MEDICAL > Pharmacy.; Electronic books.
• Φυσική περιγραφή: 1 online resource.
• Βιβλιογραφία: References; Part Two: Data; 4 BIOSTER: A Database of Bioisosteres and Bioanalogues; 4.1 Introduction; 4.2 Historical Overview and the Development of BIOSTER; 4.2.1 Representation of Chemical Transformations for Reaction Databases; 4.2.2 The Concept of ''Biosteric Transformation''; 4.2.3 Other Analogue and Bioisostere Databases; 4.3 Description of BIOSTER Database; 4.3.1 Coverage and Selection Criteria; 4.3.2 Sources; 4.3.3 Description of the Layout of Database Records; 4.3.3.1 ID Code; 4.3.3.2 Biosteric Transformation; 4.3.3.3 Citation (s) ; 4.3.3.4 Activity; 4.3.3.5 Fragments.
• ISBN: 9783527654307; 3527654305; 9783527654338; 352765433X; 9781280778537; 1280778539
• DOI: 10.1002/9783527654307

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologi.