Natural products : discourse, diversity and design /

• Other Authors: Osbourn, Anne E. (Editor), Goss, Rebecca J. (Editor)
• Format: eBook
• Language: English
• Published: Ames, Iowa ; Chichester, West Sussex, UK : John Wiley & Sons, 2014.
• Subjects: Natural products.; Biological products.; SCIENCE > Life Sciences > Biology.; Biological Factors.; Microbiological Phenomena > genetics.; Biochemical Phenomena > genetics.; Drug Discovery.; Synthetic Biology > methods.; Electronic books.

"Natural Products: Discourse, Diversity and Design provides an informative and accessible overview of discoveries in the area of natural products in the genomic era, bringing together advances across the kingdoms. As genomics data makes it increasingly clear that the genomes of microbes and pla...

Table of Contents:

• Natural products in the natural world
• Role and reason
• Self-protection: avoiding autotoxicity
• Fishing and pharming
• From genes to molecules
• Reading the genome
• Biosynthesis and heterologous expression
• Regulation: waking sleeping pathways
• Evolving enzymes, evolving pathways: synthetic biology
• Chemical diversification
• Evolving pathways
• Synthetic biology
• Screening for bioactivity
• Image-based screening approaches to natural products discovery
• Making sense of structures by utilizing Mother Nature's chemical libraries as leads to potential drugs
• Is there an ideal d1atabase for natural products research?
• To application
• Case studies.