Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

• Main Authors: Tveito, Aslak (Author), Lines, Glenn T. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Cham : Springer International Publishing : Imprint: Springer, 2016.
• Series: Lecture Notes in Computational Science and Engineering, 111
• Subjects: Mathematics.; Computer graphics.; Computer mathematics.; Computational Science and Engineering.; Biomedicine general.; Computer Imaging, Vision, Pattern Recognition and Graphics.

Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by chan...