CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

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The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body’s own constituents thus preserving its integrity. Multiple mechanisms work in concert to ensure self-tolerance. Apart from purging the T cell repertoire from auto-react...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Compans, R.W (Editor), Cooper, M.D (Editor), Honjo, T. (Editor), Koprowski, H. (Editor), Melchers, F. (Editor), Oldstone, M.B.A (Editor), Olsnes, S. (Editor), Potter, M. (Editor), Vogt, P.K (Editor), Wagner, H. (Editor), Kyewski, Bruno (Editor), Suri-Payer, Elisabeth (Editor)
Format: Electronic eBook
Language:English
Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 2005.
Series:Current Topics in Microbiology and Immunology, 293
Subjects:
Medicine.
Immunology.
Biomedicine.
Online Access:Full Text via HEAL-Link
Table of Contents:
  • Origin and Generation
  • Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides
  • The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology
  • Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Repertoires Undergoing Positive or Negative Selection
  • Selection and Behavior of CD4+ CD25+ T Cells In Vivo: Lessons from T Cell Receptor Transgenic Models
  • Migration Rules: Functional Properties of Naive and Effector/Memory-Like Regulatory T Cell Subsets
  • Peripheral Generation and Function of CD4+CD25+ Regulatory T Cells
  • Dendritic Cells: Key Cells for the Induction of Regulatory T Cells?
  • Involvement of Disease Models
  • Autoimmune Gastritis Is a Well-Defined Autoimmune Disease Model for the Study of CD4+CD25+ T Cell-Mediated Suppression
  • Regulatory T Cells in Experimental Colitis
  • Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: The Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control
  • Regulatory T Cells in Transplantation Tolerance
  • CD4+CD25+ Regulatory T Cells in Hematopoietic Stem Cell Transplantation
  • Naturally Arising CD25+CD4+ Regulatory T Cells in Tumor Immunity
  • Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells.

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